Could dysregulation of RASSF1 expression be a mechanism of tumorigenesis in CTVT?

ABSTRACT: Canine transmissible venereal tumor (CTVT) is the oldest known somatic cell lineage. It a cancer that propagates naturally in dogs and reportedly contains gene mutations. RASSF1 participates DNA damage repair, its downregulation, results progression. Hence, suppressor gene. Its expression was quantified tumors from seventeen animals three cultures derived tumors. In general, underexpressed 65%, absent 35% of samples. Cells tissue showed decreased 67% elevated 33% samples tested. The tissues significantly lower levels compared to cultured cells. Previously we reported both microenvironment host immune system appear influence tumorigenesis stage CTVT. This first article demonstrate Decreased possibly helps